The compound thinking about what could happen over 2 years of storage is going to go up. It has a better chance of dissolving in the blood. We would probably have a simple solution for each of the 3 different temperatures, the blood plasma compound and the water in the solution. In the case of compound b, it is very water-soluble. If we wanted to get compound a in solution, we would either have to use an organic solvent such as d m s, or use an amine group to make it cationic. Since nothing is ever truly perfect, identify one potential disadvantage to your recommendation.įor the long term stability studies in solution, we would want to have at least 3 sam poles, at each of the 3 different temperatures. Since nothing is ever truly perfect, identify one potential disadvantage to your recommendation.ĭiscuss the feasibility of each of the four candidates for this " \( R \) " substituent in light of the binding site restrictions, and make recommendation to your synthetic team. The molecular region of your lead compound (known as lunamine) that will interact with the site is shown in the following figure as "R".ĭiscuss the feasibility of each of the four candidates for this " R " substituent in light of the binding site restrictions, and make recommendation to your synthetic team. narrow channel within the protein) and lined with Ala, Trp, and Tyr residues. The binding site has been modeled and one specific area is known to be sterically restricted (e.g. The goal is the development of a drug that will inhibit unwanted growth of new blood vessels, and be of use in the treatment of "wet" macular degeneration and cancer. Question: As a medicinal chemist of drug design in a local company you are a team leader and tasked to construct a structure that will bind with high affinity to novel binding site on the VEGF (vascular endothelial growth factor) protein.
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